The article examines the processes involved in dismantling the Septizonium and transporting its building materials, peperino stones, to one of several sites – in this case the lavatore del Termine. References to other materials and sites such as the casa dei mendicanti are only made to support the main thesis that this was a case of rational, economical and utilitarian re-use. The main sources used were the conto misura et stima of Domenico Fontana and the transportation libretto of Giovan Pietro. The article focuses on the dismantling process itself, the time and materials it required, the working process, economic effort and interim storage. Transportation aspects are examined in terms of volumetric masses for transportation, mobility and destination routes in the incipient Sistine street system.